Rongshuantaimei(Plasmin-Ⅱ)

The main function of fibrinolytic enzymes is to dissolve excess fibrin produced by the body for various reasons, such as injury. However, fibrinolytic enzyme does not exist independently. It forms a fibrinolytic enzyme system with fibrinogen, fibrinogen activator and fibrinogen inhibitor. Any factor that activates fibrinogen can increase the activity of fibrinolytic enzyme. For example, after the partial degradation of urokinase in human blood, a serine protease is excreted from urine, which is the blood plasminogen activator. It can convert plasminogen into plasmin to dissolve embolism in blood vessels to treat cardiovascular diseases such as stroke.

 Product Development  Background

When livestock and poultry suffer from escherichia coli, infectious bronchitis, mycoplasma, H9, Newcastle disease and other diseases, a large number of fibrous exudates exudate from the chest, abdominal cavity and respiratory tract, and these exudates may cause injury or even death to the body. Therefore, in some cases it is often not enough to treat the disease without controlling the symptoms. Zhongnongfuxing biotechnology company's researchers  collaboratiing with professional research institutions ‘experts and researchers, using the research achievements of eliminating vascular embolism and scar tissue in human  for reference, have created a revolutionary product called “Rongshuantaimei”  that can effectively activates the body's fibrinolytic enzyme. This product is mainly used for fibrin embolization, and also has the effects of antiviral, cardiac strengthening, diuretic and uric acid excretion, protecting liver and improving the body’s disease resistance.

This product has a good effect on fibrin exudation caused by various reasons, such as heart and liver coated by fibrin exudate, air sac turbidity,tracheal exudation obstruction, and renal enlargement.Using this product in conjunction with effective drugs against the underlying problems can significantly reduce mortality within 12hours ,after 36 hours later, those typical symptoms can be significantly controlled .

 Clinical Case

In one of the chicken houses of a large broiler farm, 30,000 chickens,  aged 35 days, became ill on April 14, 2019, which mainly characterized by watery eyes, nose shaking, cough and pooping yellowish-white thin feces.The mental state of the large group was not good,and there was a decrease in food intake. At that time it was diagnosed as e. coli ,or mycoplasma, or bronchitis infection,and then used  the  drugs  of  doxycycline, gentamicin and  lincomycin by the way of dissolving them into drinking water, but  the drugs did not work.After 3 days, sick chickens became depressed and gradually wasted away, and the number of deaths increased rapidly.

By dissecting the dead chickens’body,it was found out that the laryngeal trachea hemorrhaging  and attached with  yellowish-white  cheese-like  exudates and blood clots ,and  the  bronchi was blocked by  cheese - like exudates,which was the leading cause of death by asphyxiation.

On the morning of April 19, began to use“Plasmin-Ⅱ” by adding it  in drinking water continuously for 3 days.An autopsy of the dead chickens the next day revealed a decrease in bronchial caseous exudate and a rapid decline in mortality, which was reduced to normal levels by April 23.

Methods And Key Points of Clinical Application

Since the launch of " Plasmin-Ⅱ", the market feedback has been good. Although the majority of dealers and farmers recognized the effectiveness of the product, but there are also a few users told us the application effects were not good.After a lot of market researchments had been done ,we found the reasons for the difference in feedback.  we must be familiar with the main ingredients of  some kind of medicine, mechanism of action, usage and dosage, adverse reactions, and how to combine with other drugs , etc.We can obtain a good therapeutic effect only by  giving  full paly to the fuctions  of the drug.

According to basic pathological changes, inflammations can be divided into alterative inflammation, exudative inflammation and proliferative inflammation." Plasmin-Ⅱ" is targeted at exudative inflammation, and its main components are fibrinolytic enzyme activator and capillary dilator.The fibrinolytic activator is absorbed by the body to stimulate the production of protease, an enzyme whose primary function is to dissolve inflammatory exudates in the body.

 Rhinitis, infectious bronchitis, infectious laryngitis, Newcastle disease, influenza, mycoplasma, escherichia coli and other diseases can cause exudative inflammations of nasal cavity, trachea, bronchus, lung, air sac,pericardium, liver, oviduct and otherorgans,presenting symptoms such as nasal sling, coughing, snoring, open-mouth breathing, pericarditis, perihepatic inflammation, salpingitis and so on." Plasmin-Ⅱ" can effectively relieve the symptoms of these diseases.

" Plasmin-Ⅱ" is like the "cleaner" in the animal body. Although it can remove the garbage already produced in the body, it can not stop the production of garbage. In order to thoroughly solve this problem, we must find the cause of producing garbage and find the person who puts out the garbage, that is to say, the pathogen of the disease.How do you identify pathogens?

How to accurately diagnosethe disease is the first step to treat .But  the current chicken diseases  are characterized by mixed infections and atypical symtoms,which bring a lot of difficulties in making the fianl diagnosis.Once the diagnosis conclusion is wrong ,the resulting wrong remedy will  cause huge economic losses.

Only choosing the sensitive drug treatment after getting the correct diagnosis can achieve significant results.  For example: if the pathogenic bacteria which is  e. coli is more sensitive to amide alcohols antibiotics, the ideal therapeutic drugs should be  amides alcohols (fluorfenicol)  and  fibrinolytic enzyme(.Plasmin-Ⅱ). “Flufenicol” kills pathogens and " Plasmin-Ⅱ" dissolves fibrin exudates,the combination of the two drugs will be very effective. But if some insensitive antibiotic were chosen instead,the production of fibrin exudates would not be controlled effectively ,although the " Plasmin-Ⅱ"works very well, the therapeutic effect still would  be poor.

Other Effects

" Plasmin-Ⅱ"has a guiding role to the distribution of antibiotics while used in conjuction with antibiotics, can enhance the blood concentration of antibiotics in injured tissues and diseased organs,making the  therapeutic effect even better. This product also has the effects of antiviral, cardiac strengthening, diuretic and uric acid excretion, protecting liver and improving the body’s disease resistance.

Application in Broiler Chicken breeding

 Currently,the biggest risk is disease in broiler chicken breeding ,which can cause great economic loss.The inflammatory reactions ,such as  redness ,swelling ,fever,pan and dysfuction are a common feature of  most diseases. At the beginning of the disease , the inflammatory response is relatively mild, this is the best time to treat.But in most cases, the farmers often not pay enough attention to the disease in this phase, not willing to invest in preventive medicines.  When the disease is serious, not only the treatment is more difficult,but also the  cost is very high, and  also it’d be easy to have an adverse impact on the production of broiler chickens later.

Therefore,to change the breeding concept is very important. Sticking to the traditional breeding concepts,such as "Only focus on treatment, not on prevention;Focus only on one point in the breeding process, not the whole breeding process;Indulging in habits without innovation "is not working well in modern farming conditions.

Since its introduction into the market, " Plasmin-Ⅱ" has played its own role in some disease prone areas and cured many intractable diseases such as pneumonitis, pericarditis, perihepatic inflammation and mixed infection, and has been highly trusted and praised by veterinarians and farmers.

In the breeding process of broiler chickens, respiratory tract disease is a frequent and common disease, which can be found  as early as 5-7 days of age, caused by vaccines, temperature, pathogenic bacteria and poor feeding management, resulting in catarrhal inflammation or serous inflammation of the trachea.It would be the best time to use”Plasmin-Ⅱ”while the inflammatory response was mild.At that  time, it can rapidly dissolve and absorb exudates, and can also work cooperatively with antibiotics to increase the distribution and concentration of drugs in focus tissues, greatly accelerating the recovery of diseases, eliminating the chance of other bacterial and viral infections, and completely eliminating the hidden dangers of secondary infections.But if the treatment is not thorough, it would be easy to cause respiratory tract mucous membrane injury, the bacteria and viruses can infect the body through the injured mucous membrane at any time,it is just like a bomb can explode at any time, thus causing great economic losses,forming a  “ the loss outweights the gain” situation.

According to statistics, e.coli can be found and isolated in 90% of chicken respiratory diseases. so respiratory diseases would be easy to cause septic e. coli, pericarditis, perihepatic inflammation and other diseases.   Normally farmers would add anti-escherichia coli drugs once to their feed every three days ,which not only increasing  costs, but also making it easy to develop drug resistance.Using " Plasmin-Ⅱ" and  anti- escherichia coli drugs at the same time can prolong the  drug use interval  by 5-7 days, reducing  the dosage, protecting  liver and kidney functions, saving  costs, and reducing  the drug  resistance of bacteria.

"Plasmin-Ⅱ" has a very obvious  preventive and therapeutic effect on respiratory tract diseases and escherichia coli diseases. At present, it has been solving problems for breeding enterprises and farmers in the three traditional breeding regions of northeast China, shandong, henan, hebei, jiangsu, anhui, guangdong and fujian province,  creating  good  economic benefits.

The excellent efficacy of" Plasmin-Ⅱ" has been tested in practice, and we believe that it will be known, recognized and trusted by more people in the breeding industry, helping the development of broiler breeding.